High On Life isn’t an open-world shooter, instead, we can expect unique alien worlds acting as stages, each housing individual challenges and loot, along with a cartel boss at the end. A small early moment of the trailer shows a grid of enemy portraits on a touch screen, listed as bounties. Think of this similar to the structure of a Mega Man game, giving us the option for the order in which we take down smaller bosses before challenging the big bad.