The game retains the same basic plot as the original. Set in the 26th century, the story follows engineer Isaac Clarke, a crewman on a repair vessel assigned to the USG Ishimura, a massive planetary mining ship that has gone silent. While investigating a distress call sent by the ship’s medical officer Nicole Brennan (Isaac’s girlfriend), the vessel’s crew is attacked by mutated human corpses; Isaac is forced to fend for himself as he tries to save his surviving crewmates and learn the truth behind the loss of Ishimura.